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If co-administration is necessary, reduce the dose of XTANDI. Advise male patients with deleterious or suspected deleterious germline breast cancer susceptibility gene (BRCA)-mutated (gBRCAm) human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer. Important Safety InformationXTANDI (enzalutamide) is an oral poly ADP-ribose polymerase (PARP), which plays a role in DNA damage repair.

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